When GABA is released from the presynaptic neuron, it travels across the synapse and binds to GABA receptors on the postsynaptic neuron. The passage of chloride ions into the postsynaptic neuron depends on the inhibitory neurotransmitter GABA. The drugs appear to act at the limbic, thalamic, and hypothalamic levels of the CNS to produce anxiolytic, sedative, hypnotic, skeletal muscle relaxant, and anticonvulsant effects (Comerford & Durkin, 2022).Īt the cellular level, the speed of impulses from a presynaptic neuron across a synapse is influenced by the number of chloride ions in the postsynaptic neuron. Let’s take a closer look at the mechanism of action for benzodiazepines.īenzodiazepines enhance or facilitate the action of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS that suppresses the activity of nerves. The precise action of benzodiazepines is not fully understood but they have been found to work selectively on polysynaptic neuronal pathways throughout the central nervous system (CNS). Facing Ethical Challenges with Strength and Compassionīenzodiazepines are a class of drugs used to treat generalized anxiety disorder, tension, insomnia, seizure disorders, procedural/surgical sedation or amnesia, skeletal muscle spasm, tremor, and delirium (Comerford & Durkin, 2022).Establishing Yourself as a Professional and Developing Leadership Skills.Ensuring Patient & Family Centered Care.Developing Critical Thinking Skills and Fostering Clinical Judgement.Alteplase Injection for Acute Ischemic Events.Lippincott Clinical Conferences On Demand.Continuing Education Bundle for Nurse Educators.Lippincott NursingCenter’s Critical Care Insider.Lippincott NursingCenter’s Career Advisor.COVID-19 2022 Update: The Nursing Workforce.An Unforeseen Path from Critical Care Nurse to Editor-in-Chief of American Journal of Nursing.When Nurses Speak, People Listen: An Interview with Pat Patton.Innovation and Solutions to Challenges in Nursing Education.Psychological Safety and Learner Engagement: A Conversation with Dr.Fostering a Safe and Healthy Work Environment through Competency-Informed Staffing.Innovation in Nursing Education Practice: A Conversation with Linda Honan. Clinical Judgment: The Doing that Happens after Critical Thinking.
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